You can tell that the show is trying to take things seriously just by who's in the board. Some of the top people at EGM, GameInformer, GameSpot, 1Up, Official Xbox Magazine, GameTrailers and GamePro make up the board.
A full list of nominees available at the link. The big prize, Game of the Year, has the following nominations:
Elder Scrolls IV: Oblivion
Gears of War
Guitar Hero 2
Tom Clancy's Ghost Recon Advanced Warfighter
There are tons of other categories, including Best Soundtrack, Best Action Game, and the testosterone-pumped "Cyber Vixen of the Year." (Way to be taken seriously, guys). Which would you pick for Game of the Year? Any strong opinions on the other categories?